26. March 2017

Abstract A quantitative structure-property relationship (QSPR) between protein stability and the physicochemical properties of excipients was investigated to enable a more rational choice of stabilizing excipients than prior knowledge. The thermal transition temperature and aggregation time were determined for lysozyme in combination with 13 different amino acids using high throughput fluorescence spectroscopy and kinetic static light scattering measurements. On the theoretical side, around 200...

27. March 2016

In “The Lives of a Cell”, L. Thomas restated a hitherto prosaic observation as a profound conjecture, i.e, that mitochondria - the earliest aerobic bacteria - may have “created” us as a ‘symbiont utilitarian layer’ for their survival. The same can be argued for the bacteria resident in the gastrointestinal system which, to put it bluntly, may have ‘created’ us in order to feed them. There are more bacteria in the human body (>500 species) than there are human cells. Most of...

06. October 2015

The aim of the present study was to evaluate the solid state characteristics, drug release and stability of fatty acid-based formulations after processing via prilling and solid lipid extrusion. Myristic acid (MA), stearic acid (SA) and behenic acid (BA) were used as matrix formers combined with metoprolol tartrate (MPT) as model drug. More

27. July 2015

Context: We previously designed, developed and characterized a novel microencapsulated formulation as a platform for the targeted delivery of Probucol (PB) in an animal model of Type 2 Diabetes. Objective: The objective of this study is to optimize this platform by incorporating Chenodeoxycholic acid (CDCA), a bile acid with good permeation-enhancing properties, and examine its effect in vitro. More