08. March 2017

Abstract Moisture activated dry granulation (MADG) method was used to develop IR tablets with cohesive, fluffy and high dose drugs. To evaluate this approach, three drugs: metformin hydrochloride, acetaminophen and ferrous ascorbate were selected as model compound along with three binders: maltodextrin DE16, PVP K 12 and HPC. The granules were generated using MADG method and tablets were prepared using rotary tablet press. The granules and tablets were characterized for particle size analysis,...

17. February 2016

This study evaluated the effects of changing the amount of added water for moisture activated dry granulation (MADG) on the resulting granule characteristics and tablet properties. Water soluble fillers and binders were pre-mixed in a granulator, and the binder was activated by a small amount of water to form granules. The amount of added water was defined as the percentage of granulation water by mass to charged powder. Granules made with 0.0%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%, and 5.0% (w/w)...