07. July 2016

Abstract An in vitro biorelevant gastrointestinal transfer (BioGIT) system was assessed for its ability to mimic recently reported albendazole concentrations in human upper small intestine after administration of free base suspensions to fasted adults in absence and in presence of supersaturation promoting excipients (hydroxypropylmethylcellulose and lipid self-emulsifying vehicles). The in vitro method was also used to evaluate the likely impact of using the sulfate salt on albendazole...

26. May 2015

Highlights • Solubility and dissolution of Albendazole was greatly enhanced. • Benzoic acid generated hydrogen bonding with drug and changed crystal habit. • Flow property and compressibility was significantly improved. • Bioavailability of drug was enhanced by many folds compared to pure drug. http://www.sciencedirect.com/science/article/pii/S0921883115000990 Mihir K. Raval, , Pooja D. Vaghela , Ashish N. Vachhani , Navin R. Sheth Department of Pharmaceutical Sciences, Saurashtra...