18. March 2016

Aminoglycosides are scarcely absorbed via the gastro-intestinal tract, and for that reason they are often administered by injection, which is an invasive administration technique. Tobramycin for the treatment of pulmonary infections is currently also nebulised after early inhalation studies with this drug in the 1980s showed promising results against Pseudomonas aeruginosa in Cystic Fibrosis patients. However, nebulisation has many disadvantages. The technique is ineffective, laborious and...