11. August 2017
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil®) with a size ranging from 310 to 500 μm and an average pore diameter of 15 nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain...
29. April 2016
Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for prescription and over-the-counter medications. In contrast to classical tablets, ODTs are specifically designed to disintegrate directly in the patient's mouth. The disintegrated tablet can then be swallowed easily without any resistance. BASF offers a comprehensive set of excipients that help you to easily formulate your active ingredient...
29. April 2016
Gamlen Tableting’s new flagship D series dynamic powder compaction analyzers feature dwell time control. Supplied with new “in-die” and “out-of-die” compaction analysis software, D series analyzers enable researchers to characterize the elasticity and plasticity of materials at each compaction event, as well as material lubricity and punch detachment behaviour. More
28. April 2016
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil®) with a size ranging from 310 to 500 μm and an average pore diameter of 15 nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain...
28. April 2016
Presentation by Dr Andrew Teasdale AstraZeneca IPEC Europe Excipients Forum - Making Pharmaceutics 2016 Link to pharm tech article (March 2015) IPEC Elemental Impurities Lette & Template (incl. Daily Intake Calculator)
28. April 2016
Abstract: The aim of this study was to formulate probiotics-loaded pellets in a tablet form to improve storage stability, acid tolerability, and in vivo intestinal protective effect. Bacteria-loaded pellets primarily prepared with hydroxypropyl methylcellulose acetate succinate were compressed into tablets with highly compressible excipients and optimized for flow properties, hardness, and disintegration time. The optimized probiotic tablet consisted of enteric-coated pellets (335 mg),...
28. April 2016
The search for excipients to replace microcrystalline cellulose (MCC) in the production of pellets by extrusion-spheronization in cases of drug incompatibility or the lack of pellet matrix disintegration forms the basis of this study. A combination of к-carrageenan as a spheronization aid, chitosan as a diluent, and Carbopol® 974P as a binder in the production of pellets containing no MCC has been investigated using acetaminophen as a model drug. More
28. April 2016
Our objectives were to explore the possibility of avoiding neonatal exposure to potentially harmful excipients of interest (EOI)—parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol and ethanol—through product substitution in Europe. Methods We performed a 3-day service evaluation survey and a 1-day point prevalence study in 20 and 21 European countries, respectively. Analysis included active pharmaceutical ingredients (APIs) used in ≥10 % of units. We...
26. April 2016
The work investigates the adhesive/cohesive molecular and physical interactions together with nanoscopic features of commonly used orally disintegrating tablet (ODT) excipients microcrystalline cellulose (MCC) and D-mannitol. This helps to elucidate the underlying physico-chemical and mechanical mechanisms responsible for powder densification and optimum product functionality. Atomic force microscopy (AFM) contact mode analysis was performed to measure nano-adhesion forces and surface energies...