15. February 2017

Abstract The purpose of this study was to develop and evaluate the berberine hydrochloride (HB) - Eudragit S100 solid dispersion to prolong the drug release by expoiting its pH-sensitivity dissolution. Solid dispersion of berberine hydrochloride (HB) with Eudragit® S100 (S100) was prepared by a solvent evaporation method. Based on the evaluating dissolution in vitro, the ratio of HB and S100 was optimized to 1:4. The solid dispersion formation of HB-S100 was characterized by XRD, DSC, and...

15. December 2016

Abstract There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism and efflux transport. So far, little is known whether they also modulate uptake transporter proteins. We have recently shown that commonly used solubilizing agents exert significant effects on the function of organic anion uptake transporting polypeptides. Therefore, we investigated in this study the influence of frequently used pharmaceutical...

08. November 2016

Abstract Anionic Methacrylate Copolymer (AMC) is a fully polymerized copolymer used in the pharmaceutical industry as an enteric/delayed-release coating to permit the pH-dependent release of active ingredients in the gastrointestinal tract from oral dosage forms. This function is of potential use for food supplements. Oral administration of radiolabeled copolymer to rats resulted in the detection of chemically unchanged copolymer in the feces, with negligible absorption (<0.1%). AMC is...