24. March 2017

Abstract Recent work established polymer strip films as a robust platform for delivery of poorly water-soluble drug particles. However, a simple means of manipulating rate of drug release from films with minimal impact on film mechanical properties has yet to be demonstrated. This study explores the impact of film-forming polymer molecular weight (MW) and concentration on properties of polymer films loaded with poorly water-soluble drug nanoparticles. Nanoparticles of griseofulvin, a model...

20. January 2017

INTRODUCTION Incorporating a broad range of pharmaceutical- or biologics-loaded fibers into implantable medical devices that could enable next-generation medical applications was previously not feasible because the types of drugs capable of surviving traditional fiber manufacturing processes were historically limited. Pharmaceutical- and biologics-loaded implantable textiles can result in faster healing and improved patient compliance of medical devices. However, traditional melt extrusion...

21. March 2016

Purpose The effectiveness of Tenofovir based HIV pre-exposure prophylaxis (PrEP) is proven, but hinges on correct and consistent use. User compliance and therapeutic effectiveness can be improved by long acting drug delivery systems. Here we describe a thin-film polymer device (TFPD) as a biodegradable subcutaneous implant for PrEP. Methods A thin-film polycaprolactone (PCL) membrane controls drug release from a reservoir. To achieve membrane controlled release, TAF requires a formulation...

20. March 2016

This work describes an approach to modify the release of active compound from a 3D printed model drug product geometry intended for flexible dosing and precision medication. The production of novel polylactic acid and hydroxypropyl methylcellulose based feed materials containing nitrofurantoin for 3D printing purposes is demonstrated. Nitrofurantoin, Metolose® and polylactic acid were successfully co-extruded with up to 40% Metolose® content, and subsequently 3D printed into model disk...

26. December 2015

Biopolymers are naturally occurring polymeric biomolecules. They are easily accessible, relatively cheap, can be synthetically altered and biodegradable. Locust bean gum and Xanthan gum is widely used ingredient in drug formulations due to their non interacting behavior with the drug and less toxicity. Microparticle formulations of celecoxib, a COX-2 inhibitor were formulated using Locust bean gum and Xanthan gum. More

05. May 2015

Fenretinide is an anticancer drug with low water solubility and poor bioavailability. The goal of this study was to develop biodegradable polymeric nanoparticles of fenretinide with the intent of increasing its apparent aqueous solubility and intestinal permeability... http://www.ncbi.nlm.nih.gov/pubmed/25933716 Eur J Pharm Sci. 2015 Apr 28. pii: S0928-0987(15)00179-7. doi: 10.1016/j.ejps.2015.04.024.