01. March 2018
Most of antibacterial and antiviral agents and drugs for the treatment of central nervous system and cancer are water-insoluble, which reduces their bioavailability. The bioavailability of substances can be increased by using a dosage form such as nanosuspension.
06. September 2017
Abstract This review summarizes recent progress of the robust and smart hydrogels prepared from natural polymers including polysaccharides, proteins, etc. These hydrogels exhibit outstanding mechanical properties due to their nanofibrous aggregated microstructures and special crosslinking networks. Furthermore, these hydrogels show some smart stimuli-responsive behaviors triggered by pH, temperature, light, electricity and magnetism. Hopefully, these hydrogels derived from natural polymers with...
13. December 2016
Abstract Carrageenan is a natural polysaccharide extracted from edible red seaweeds of Rhodophycea class. It has been used as a viscosity increasing or gelling agent for prolonged and controlled drug release, food, pharmaceuticals and other industries. However, in spite of wide range of applications, carrageenan has some drawbacks and adverse effects on the biological systems, so its modifications with natural and synthetic polymers are carried out. This review article presents different...
27. October 2016
Biological drugs generated via recombinant techniques are uniquely positioned due to their high potency and high selectivity of action. The major drawback of this class of therapeutics, however, is their poor stability upon oral administration and during subsequent circulation. As a result, biological drugs have very low bioavailability and short therapeutic half-lives. Fortunately, tools of chemistry and biotechnology have been developed into an elaborate arsenal, which can be applied to...
01. October 2016
Abstract Current polymeric research has explored various applications in drug delivery and its related biomedical applications. Natural polymers especially those are derived from plant sources has evidenced for growing interest and attention in biomedical and pharmaceuticals sectors. Owing to their relative abundance, low cost, and biodegradable and eco-friendly profiles, plant derived polysaccharides are more preferred over the synthetic polymers. Present work demonstrates the drug delivery...
08. August 2016
Abstract Bio-nanocomposites, composed of biopolymers and inorganic solids, show dimensions in the nanometer range (1–100 nm) which can be widely used in variety of areas owing to multidimensional properties like biocompatibility, antimicrobial activity and biodegradability. Considering these versatile properties of the bio-nanocomposites this review sheds a light on the synthesis, modification, characterization and applications of bio-nanocomposites based on different polysaccharides...
27. July 2016
Development of new products and materials, especially those which are based on renewable organic resources using innovative sustainable processes, represents an increasing interest in both academic and industrial research. Cellulose and its derivatives have demonstrated to be versatile materials with unique chemical structure which provides a good platform for the construction of hydrogel networks with distinctive properties as respects of swelling ability and sensibility to external stimuli....
29. February 2016
The development of novel biomedical materials for practical and clinical applications, such as drug carriers, biocompatible tissue or organ substitute materials, repair and regeneration biomaterials, etc., is always a most concerned topic for biologists and material scientists. Many natural materials have been used as biomedical materials to replace traditional organic synthetic materials. More
20. October 2015
Novel hydroxypropylmethyl cellulose (HPMC)-based sponges containing self-microemulsifying curcumin (SME-Cur) were prepared by a freeze drying method using different grades of HPMC (E5 LV, E15 LV, E50 LV, A15 LV, and A4C). The physical properties and drug release from these carriers were characterized and compared among the different formulations. The mean pore size values of the sponges from image analysis ranged from 43.36 ± 4.54 to 123.22 ± 8.19 nm. More
16. February 2015
Denise F. S. Petri* Article first published online: 16 FEB 2015 DOI: 10.1002/app.42035 http://onlinelibrary.wiley.com/doi/10.1002/app.42035/abstract