28. August 2018
Please find all blog articles by pharmaexcipients from August 2018 with direct links in case you missed some. Freeze-drying of Monoclonal Antibody-Conjugated Gold Nanorods: Colloidal Stability and Biological Activity Effect of powder properties on the aerosolization performance of nanoporous mannitol particles as dry powder inhalation carriers Rheological and mucoadhesive properties of polysaccharide from Bletilla striata with potential use in pharmaceutics as bio-adhesive excipient Main...
11. August 2017
The goal of this study was to test the feasibility to load non-ordered, non-spherical mesoporous silica with the model drug paracetamol, and subsequently coat the loaded particles using one single pilot scale fluid bed system equipped with a Wurster insert. Mesoporous silica particles (Davisil®) with a size ranging from 310 to 500 μm and an average pore diameter of 15 nm were loaded with paracetamol to 18.8% drug content. Subsequently, loaded cores were coated with ethylcellulose to obtain...
05. June 2017
Ultrasound-assisted compression (USAC) is a technology combining a conventional compression process and US irradiation. These mechanical and thermal effects lead to heating, melting and sintering of materials.
31. May 2017
In a nanotechnological approach we have investigated the use of natural lipids in the preparation of nanostructured lipid carriers (NLC).
24. May 2017
Many commonly used tablet fillers are not suitable for direct compaction process due to insufficient properties, mainly of flowability and compactability. This work therefore aimed to use co-spray drying with HPMC as a platform to improve direct compaction properties of various tablet fillers.
24. May 2017
EXCiPACT asbl is delighted to announce that the Sigachi Industries Pvt. Ltd.’s site in Dahej, India has recently been awarded an EXCiPACT GMP Certificate from SGS, one of EXCIPACT’s internationally-recognised Certification Bodies.
23. May 2017
The performance of a drug is primarily influenced by the disintegration and dissolution behaviour of the powder compact.
22. May 2017
Poor water-solubility is a common characteristic of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate and bioavailability of these active ingredients belonging to BCSII and IV classifications. Over the last decade, nano-crystal delivery forms and amorphous solid dispersions have become well established in commercially available products and industry literature. Chapter 1 is a comparative analysis of...
22. May 2017
Nowadays, biopolymers, a class of biomaterials, represent frontier area in the drug delivery systems. Drug release from nano- and microparticles is a complex process, which involves several steps. Uptake of nanoparticle in the intracellular is affected by numerous factors. Recently, gene delivery has been considered one of the promising approaches for the treatment of various diseases acquired genetically in human being.
22. May 2017
Minimally-porous solid and cellular dosage forms at various weight fractions of PEG excipient and Acetaminophen drug have been prepared and tested for drug release. The disintegration rate of the surface-eroding solid forms is affected by the drug weight fraction, but that of the exfoliating cellular forms is not. Models are developed to elucidate the effect of the drug weight fraction on disintegration and drug release by the solid and cellular dosage forms.