05. April 2017

Abstract Local delivery of drugs and biopharmaceuticals for the treatment of inflammatory bowel disease remains a challenge. Innovative nanomedicines with appropriate properties raise the possibility of efficient drug targeting. Hence, the overall aim of this study was to develop and characterize a protamine-based nanosystem for topical delivery of therapeutics to inflamed intestinal mucosa following oral administration. Protamine nanocapsules with a new composition were for the first time...

18. September 2016

Inflammatory bowel disease (IBD) is an idiopathic, relapsing disease involving chronic inflammation of the digestive tract, either in part or entire. IBD primarily includes Crohn’s disease (CD) and ulcerative colitis (UC) with a high prevalence rate in the industrialized world, with North America noting the highest frequency of people suffering with CD [1]. Incidence of IBD is from 31 to 71 per100,000 people for CD and 18-31 per 100,000 for UC and is increasing at an alarming rate. Although,...

24. November 2015

Two well-known active agents, Mesalamine (MES) and Sucralfate (SUC), were investigated for possible utilisation as fixed-dose combination product. The anti-inflammatory action of MES in association with bioadhesiveness and mucosal healing properties of SUC were considered promising for the development of a new compound containing both molecules, aimed as an improved treatment of ulcerative colitis. More

09. June 2015

Abstract The Plantago is one of the genera in family Plantaginaceae, a large genus of herbs or sub-herbs distributed mostly in the temperate region and a few in the tropics. Psyllium has been in use as a medicinal agent since ancient times throughout the world. It is used for treatment of constipation, diarrhea, hemorrhoids, and high blood pressure. In olden days it was also used topically to treat skin irritations, such as poison ivy reactions and insect bites and stings. The husk of the seeds...