26. September 2018
Wet granulation is a size-enlargement process applied in many industrial fields, such as pharmaceutical, nutraceutical, zootecnichal, to improve flowability and compressibility properties of powders. In this work analysis of the particle size distribution (PSD) of granules was performed to understand the phenomena involved during the granulation process and to optimize the operating conditions. Hydroxypropyl methylcellulose (HPMC) granules were produced spraying distilled water as liquid binder...
07. May 2015
•Tests with coloured pastes show that fines do not attach preferentially at pellet waist. •New ‘dumb-bellity’ measure to quantify the formation of dumb-bells •Spheronisation time increases with mass of charge until overmassing occurs. •Tests with calcium carbonate as model API exhibit the same behaviour. http://www.sciencedirect.com/science/article/pii/S003259101400864X