17. July 2016

Background: Introducing the concept of mucoadhesion in the 1980s, application of mucoadhesive polymers for buccal drug delivery has been the subject of pharmaceutical interest. Aim: The purpose of this study was to modify well-known xanthan in order to remarkably boost its suitability for buccal adhesiveness. Method: Xanthan (X) was chemically modified by covalent binding of L-cysteine (SH) exhibiting sulfhydryl groups on the polymeric backbone via amide bond formation. Cytotoxicity, stability...