10. January 2017

Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS) was developed, which consisted of chitosan (CTN) based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two- level factorial design method. Drug-release characteristics in terms of dissolution ef ciency and controlled-release...

08. December 2015

Highlights • Geldart group C ibuprofen particles were silica dry coated to enable fluidization. • Aeration testing and flow function coefficient were indicative of fluidizability. • Dry coated ibuprofen powders could be fluidized and polymer film coated. • Polymer suspensions with stabilized colloidal silica led to reduced agglomeration. • Scalable coating conditions were determined for the micronized ibuprofen powders. More

13. August 2015

Besides the known propolis biological activities, widely reported in many scientific studies, new findings in animal models have opened new fields for propolis application. Recently, there has been an increased interest in dried extracts based on natural products including propolis, as the product in the dry presentation shows several advantages. Therefore, standardizing a more soluble dry extract and allowing the production of human dosage forms are of great interest. In this context, this...