19. April 2017

Abstract The objective of this study was to investigate the effect of the different physiological parameters of the gastrointestinal (GI) fluid (pH, buffer capacity, and ionic strength) on the in vitro release of the weakly basic BCS class II drug quetiapine fumarate (QF) from two once-a-day matrix tablet formulations (F1 and F2) developed as potential generic equivalents to Seroquel® XR. F1 tablets were prepared using blends of high and low viscosity grades of hydroxypropyl methylcellulose...

23. March 2017

Abstract The pharmaceutical industry has seen an increased need of carriers or excipients design that allows the controlled release of a drug in the human body. The main role of an excipient is to carry the drug for its administration under therapeutic index. Among the new generation of excipients, the ordered mesoporous silica (MS) presents several advantages, such as excellent biocompatibility, good adsorption capacity, and precise control in the drug delivery. However, the high cost of...

14. June 2016

Heat sealing property of self-supporting edible films based on corn starch and a functional polysaccharide, such as amylose (AM), methylcellulose (MC) or hydroxypropylmethylcellulose (HPMC) was evaluated. Films were prepared in the laboratory by casting and heat sealed at 85–166 °C by an impulse heat sealer. Irrespective of film composition, sealing temperature influenced the seal strength. Films sealed at temperature <143 °C showed peeling mode failure attributing to weak seal strength,...

07. June 2016

Purpose To investigate if drug solubility in pharmaceutical excipients used in lipid based formulations (LBFs) can be predicted from physicochemical properties. Methods Solubility was measured for 30 structurally diverse drug molecules in soybean oil (SBO, long-chain triglyceride; TGLC), Captex355 (medium-chain triglyceride; TGMC), polysorbate 80 (PS80; surfactant) and PEG400 co-solvent and used as responses during PLS model development. Melting point and calculated molecular descriptors were...

20. March 2016

The aim of this study is to propose a new electrochemical method for the evaluation of the antioxidant capacity of the pharmaceutical antioxidant excipient in drugs. The evaluation was conducted by integrity testing of DNA bases, which were modified on an electrode. Guanine was selected as the electrochemical probe. Based on the changes of the oxidation current of guanine on a modified glassy carbon electrode (GCE), the protective capacity of the antioxidant for guanine was determined. TiO2...