19. January 2018
The authors studied six different grades of HPC to determine how they performed in high-shear and fluid-bed granulation.
06. November 2017
Many efforts have been made in the past to understand the function of lactose fines which are given as a ternary component to carrier-based dry powder inhaler formulations. It is undisputed that fines can significantly improve the performance of such formulations, but choosing the right amount of fines is a crucial point, because too high concentrations can have negative effects on the dispersion performance
15. October 2016
Abstract Metamizole is an effective non-opioid analgesic drug used in the treatment of acute and chronic pain. Due to induced potentially life-threatening blood disorders, metamizole was withdrawn from market in many parts of the world, however, it is one of the most popular analgesics in Poland that is available as an over the counter drug. Patients tend to prefer capsules over tablets, as they are easier to swallow and taste better. The powder-filled capsules also have greater bioavailability...
10. August 2016
Abstract The objective of this study was to analyze differences in the subtle microstructure of three different grades of HMPC hard capsule shells using mechanical, spectroscopic, microscopic and tomographic approaches. Dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), vibrational spectroscopic, X-Ray scattering techniques as well as environmental scanning electron microscopy (ESEM) and optical coherence tomography (OCT) were used. Two HPMC capsules manufactured via chemical...
03. August 2016
Abstract In this work, a platform of alginate beads loaded with Prednisolone in hypromellose/gellan gum capsules (F6/Cps) able to delay steroidal anti-inflammatory drug (SAID) release as needed for chronotherapy of rheumatoid arthritis is proposed. Rheumatoid arthritis, showing a worsening in symptoms in the morning upon waking, is a pathology that can benefit from chronotherapy. With the aim to maximize prednisolone therapeutic action allowing the right timing of glucocorticoid therapy,...
02. August 2016
EXCiPACT asbl is pleased to announce that ACG Associated Capsules has recently been awarded an EXCiPACT Certificate from SGS, one of EXCIPACT’s internationally-recognised Certification Bodies. The Certificate demonstrates that ACG Associated Capsules site in Thanes, Maharashtra, India, manufactures pharmaceutical excipients according to the EXCiPACT Good Manufacturing Practice (GMP) Certification Standard. Its scope covers manufacturing of Hard Gelatin Capsule Shells IP, Hard Gelatin Capsule...
09. October 2015
"Making mini-formulations of excipients in the lab and assessing their processability and stability cannot capture the full potential for variability. It’s better to map an API’s susceptibilities to potential degradation pathways, followed by a risk-based assessment that reveals an excipient’s impurity profile." More
23. September 2015
Carolina Diaz-Quijano explains how it performs in tablets, orally disintegrating tablets, and orally disintegrating granules. More