03. May 2017

Carbamazepine is an anticonvulsant and moodstabilizing drug used in the treatment of epilepsy and bipolar disorder. Certain limitations associated with the oral administration of the drug are poor water solubility, complexity in polymorphism, autoinduction to metabolism, narrow therapeutic window and high therapeutic dosage requirements.

26. April 2017

Abstract The aim was to develop immediate-release carbamazepine tablets consisting of self-emulsified drug delivery system (SEDDS) by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental...

08. March 2017

Abstract Poor aqueous solubility is a major concern for many new drugs. One possibility to overcome this issue is to formulate the drug as a high energy form, i.e. a metastable polymorph, an amorphous neat drug or a glass solution with polymers. In this study the dissolution properties of different solid state forms of carbamazepine, crystalline or amorphous drug, with or without either polyvinylpyrrolidone (PVP) or hydroxypropylmethylcellulose (HPMC) and glass solutions of the drug with both...

12. February 2017

Abstract Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcome stability issues that may arise from the conversion of a crystalline drug into its amorphous form. In this study, quench cooling was used to prepare co-amorphous forms of carbamazepine (CBZ) with saccharin (SAC), lactose (LAC) and gluconolactone (GLU) as carriers. Analytical techniques such as...

31. May 2015