22. March 2017

Abstract: Triterpene compounds like betulin, betulinic acid, erythrodiol, oleanolic acid and lupeol are known for many pharmacological effects. All these substances are found in the outer bark of birch. Apart from its pharmacological effects, birch bark extract can be used to stabilise semisolid systems. Normally, birch bark extract is produced for this purpose by extraction with organic solvents. Employing supercritical fluid technology, our aim was to develop a birch bark dry extract suitable...

09. August 2016

Abstract This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w) of metolose (MET) with polyethylene glycol (PEG 400) (0.5% w/w) as plasticiser, and l-arg (0.2% w/w) as a stabilizer and dried in an oven at 40 °C. The blank and drug loaded films were divided into two groups, one group was subjected to...

06. July 2016

Abstract The phase transition of pharmaceutical excipients that can be induced by humidifying or heating is well-known to increase the hardness of orally disintegrating tablets (ODTs). However, these conditions are not applicable to drug substances that are chemically unstable against such stressors. Here, we describe a system which enhances the hardness of tablets containing water-insoluble polymers by using high-pressure carbon dioxide (CO2). On screening of 26 polymeric excipients,...

25. December 2015

The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the Particles from Gas Saturated Solution (PGSS) process and how process parameters affect the physico-chemical properties of shellac. More

06. October 2015