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20. April 2015
ABSTRACT The aim of this study was to evaluate the direct compression behaviour of co-processed cassava starch and colloidal silica in the formulation of metronidazole tablets. Cassava starch was extracted from freshly harvested roots of Manihot glaziovii obtained from IITA farms, Shika, Zaria. Subsequently, it was co-processed with colloidal silica at varying ratios (95:5, 96:4, 97:3, 98:2 and 99:1). Preliminary screening was conducted on the five combinations by determining the crushing...