10. January 2017

Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS) was developed, which consisted of chitosan (CTN) based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two- level factorial design method. Drug-release characteristics in terms of dissolution ef ciency and controlled-release...

04. January 2017

Active ingredients in pharmaceuticals di er by their physico-chemical properties and their bioavailabil- ity therefore varies. e most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. us they are not su ciently e ective and suitable for such administration. For this reason a system of lipid based formulations (LBF) was developed. Series of formula- tions were prepared and tested in water and biorelevant media. On the...

15. December 2016

Abstract There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism and efflux transport. So far, little is known whether they also modulate uptake transporter proteins. We have recently shown that commonly used solubilizing agents exert significant effects on the function of organic anion uptake transporting polypeptides. Therefore, we investigated in this study the influence of frequently used pharmaceutical...