09. August 2017

The present study was done for improvement of solubility and thereby bioavailability of Cefixime for its e cient an microbial activity by using amphiphilic Soluplus as a carrier. Different methods were used for enhancing the solubility of Cefixime like physical mix, kneading, microwave irradiation, solvent evaporation, lyophilization and spray drying. The plain drug and the prepared SD with various CFX to polymer ratios were characterized in terms of solubility, drug content, IR, DSC, SEM, XRD,...

26. March 2016

For many water insoluble acidic or alkaline drugs, amorphization and nanonization represent an effective bioavailability enhancement strategy. Cefixime (CFX) was chosen as a model drug, and amorphous nanoparticles were prepared via a typical process intensification technology: high-gravity reactive precipitation (HGRP). The effects of temperature, rotating speed, overall flow rate, and drug concentration on the particle size and size distribution were investigated. Under the optimum conditions,...

10. March 2016

ABSTRACT Six batches of formulated sustained release matrix tablets of Cefixime Trihydrate were prepared by using different polymers like Tamarind Gum, Carnauba wax, HPMC, MCC, PVP K30 by wet granulation technique. The effects of prepared tablets by using natural polymers were evaluated for pre compression parameters, uniformity of content, assay and in vitro drug release. Influences of different parameters like pH, agitation intensity on drug release were also studied. Cefixime Trihydrate...