03. September 2018
Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and tablets. This study proposes the use of an in vitro model to quantitatively investigate the swallowing dynamics in presence of multi-particulates. In vitro results were compared against sensory tests that considered the attributes of ease of swallowing and...
24. August 2018
A process control system based on PAT can compensate for variations in particle size, resulting in more consistent coating thickness.
Drug-layered multiparticulates are a common dosage form for extended or modified-release pharmaceutical formulations. Delivered either in capsules, tablets, or as food additives in pediatric or geriatric applications (1), these formulations typically feature a functional coating designed to delay dissolution of the drug in the body.
18. August 2018
Older adults with multimorbidity, polypharmacy, and complex health needs are the major consumer of health care. Ensuring that medicines are used safely, effectively, and delivered efficiently in this population is challenging. In this context, the approach to medicines delivery should seek to overcome some of the difficulties of delivering medicines to older people, and ensure each medication is delivered by the optimal and most convenient route for the patient in question. However, this poses...
08. August 2018
The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality by design (QbD) approach. The drug release rate of methimazole, a freely soluble model drug, was evaluated extensively together with the mechanical strength and true density of the coated pellets. Moreover, the thermal and spectroscopic properties, as well as the surface characteristics were studied...
26. July 2018
Paediatric specific medicines have become increasingly researched since the introduction of paediatric investigation plan requirements in 2007. Various dosage forms continue to be investigated for their appropriateness for children, including multiparticulates. Multiparticulates are currently available as tablets, capsules, sachets and medicated spoons/straws/syringes. These presentations offer limited dose flexibility with some only providing a singlefixed dose. A device capable of repeated...
26. June 2018
More and more pharmaceutical products are reaching the market as multiparticulate dosage forms, mainly as pellets. The healthcare sector also frequently selects pellets as the optimal marketable form of functional food. As there are quite a number of existing techniques relating to the production of pellets, it is often very difficult for a formulator or marketing manager to make a choice, since every technique claims to be optimal.
15. March 2018
presented by Glatt @ 11th Worldmeeting on on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology -19 March to 22 March 2018 Granada, Spain On the Glatt Booth N° 3 we will exhibit our smallest continuous granulation line and inform about our solutions in micropellets, taste masking, pediatric formulation, drug delivery, etc. From our Pharmaceutical Development origin the following poster contributions: Influence of polymer content on droplet size distributions in atomized spraying...
04. March 2018
With manufacturers beginning to improve their understanding of the uses of multiparticulate products, alongside more research and progressive advancements being made, the future looks bright for pelletisation as a technique in drug development. Here, Dr Beata Vladovicova talks about the wide-ranging advantages of pelletisation, whilst also exploring the use of extrusion-spheronisation to produce these types of drugs. She also discusses the challenges faced in the development of pellets and why s
22. February 2018
Synopsis Fluidized bed granulation (FBG) is a commonly known and highly complex process in the pharmaceutical industry. In-line spatial filter velocimetry (SFV) analysis for particle size measurement provides a promising approach to enhance process control and efficiency. In the present study investigations of the installation height and the influence of differing process parameters on in-line SFV analysis were evaluated. Materials and Methods A blend of Cellets (Harke Pharma GmbH, Germany) was...
17. January 2018
Controlled release dosage forms are essential in certain dosage regimens where release rate of drug impacts the effectiveness for therapy. In the present study, modified release dosage form of Domperidone was developed in the form of pellets which were subsequently compressed into tablet to disintegrate and swallow by patients without changing the release profile.