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07. April 2017
Abstract High shear mixers are classically used for wet granulation because they provide granules with a high density and a high strength in a short granulation time. In this study, the high shear wet granulation process was employed using chlorpheniramine maleate as a model drug, since it represents an example of low dose drug employing 32 randomized full factorial design and optimized in terms of different properties using Response Surface Methodology (RSM) approach. The effect of binder...
22. March 2016
Three microcrystalline cellulose (MCC) samples were manufactured from bleached and unbleached softwood kraft pulp, and their properties were compared to those of the commercial MCC, Avicel PH-101. One of the produced samples retained a large portion of lignin (10.3%), while the two others retained only some. The physical, chemical, thermogravimetric, and molecular properties were analyzed. The presence of lignin caused a substantial effect on the thermogravimetric and chemical properties of the...
21. March 2016
Background: Quince seed mucilage biopolymer (QSMB), famous for ameliorating coughs and controlling asthma symptoms, has not been processed by scientific methods and rules into a local oral tablet. Objectives: The purpose of this study was to investigate and compare the mechanical properties of QSMB with different size fractions of the mucilage powder, dried by oven or by freeze drying, to achieve a tablet. Materials and Methods: The granules dried by oven and freezing processes were classified...
30. January 2016
This study was aimed at isolating, characterizing and evaluating the excipient functionalities of a polymer from watermelon seeds. After oil extraction, the marc was dispersed in water, agitated, filtered, the polymer harvested as the sediment in the filtrate and purified. The polymer was characterized; used as excipient in tablet formulation; and tablets' qualities were assessed using standard protocols. Physicochemical tests revealed polymer as non-polysaccharide, amorphous biomaterial with...
22. October 2015
21. August 2014
Julia Maier - EDQM ExcipientFest Europe - Amsterdam June 2014 http://www.excipientfest.com/europe/pdf/EFE14%20June%2025,%20AM%20Key%20Note%20FRC%20Characteristics%20of%20Excipients%20in%20the%20EP.pdf