20. April 2017

The aim of this thesis was to develop drug encapsulation in chitosan nanoparticles for der- mal patch formulations. The thesis project included the optimization of preparation protocols of drug capsulated nanoparticles by using a model drug and a variety of synthetic routes. Subsequently, the model drug was replaced by the local anesthetic drug, lidocaine. In addi- tion, one part of the project was to develop a thin polymer film which incorporates lidocaine- encapsulated chitosan nanoparticles....