08. March 2017

Abstract Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would deliver this hydrophilic anti-HIV drug to the reticuloendothelial system for better therapeutic efficacy. The objectives of the current study were to prepare and pharmaceutically characterize...

05. March 2016

Solubility parameters of HPMCAS have not yet been investigated intensively. On this account total and three dimensional solubility parameters of HPMCAS were determined by using different experimental as well as computational methods. In addition, solubility properties of HPMCAS in a huge number of solvents were tested and a Teas plot for HPMCAS was created. The total solubility parameter of about 24 MPa0.5 was confirmed by various procedures and compared with values of plasticizers. 20 common...

12. June 2015

he principal component of many solid pharmaceutical formulations and indeed of dry powder inhalers, rather than being an active pharmaceutical ingredient (API), is most likely to be lactose. It is an excipient that fulfils a number of functions including those of diluent, flow-aid and API carrier. More Pulmonary Drug Delivery: Advances and Challenges Published Online: 29 MAY 2015 DOI: 10.1002/9781118799536.ch7