18. February 2016

Purpose: Introduction to hot melt co-extrusion for utilization as a drug delivery method. Influence of process parameters on final drug product quality. Application of Raman imaging microscopy as a analytical tool for quality control of the co-extrudate. Methods: Co-extrusion with a newly designed co-extrusion die and a pharmaceutical relevant polymer/active formulation. Chemical mapping with Raman microscopy to provide evidence on extrudate integrity and absence of drug migration. Results: The...

17. January 2016

This study aimed to design a fixed-dose combination dosage form which provides a sustained release profile for both the freely water-soluble metformin HCl and the poorly soluble gliclazide, two antidiabetic compounds used to treat diabetes mellitus. More