31. March 2018
The growing popularity of direct-compression process necessitates an ideal filler–binder that can substitute two or more excipients. Pregelatinization of starches significantly improves swelling and flow properties but produces tablets with low mechanical strength.
23. October 2017
The development of novel excipients with enhanced functionality has been explored using particle engineering by co-processing. The aim of this study was to improve the functionality of tapioca starch (TS) for direct compression by co-processing with gelatin (GEL) and colloidal silicon dioxide (CSD) in optimized proportions.
24. November 2015
Two well-known active agents, Mesalamine (MES) and Sucralfate (SUC), were investigated for possible utilisation as fixed-dose combination product. The anti-inflammatory action of MES in association with bioadhesiveness and mucosal healing properties of SUC were considered promising for the development of a new compound containing both molecules, aimed as an improved treatment of ulcerative colitis. More
20. April 2015
ABSTRACT The aim of this study was to evaluate the direct compression behaviour of co-processed cassava starch and colloidal silica in the formulation of metronidazole tablets. Cassava starch was extracted from freshly harvested roots of Manihot glaziovii obtained from IITA farms, Shika, Zaria. Subsequently, it was co-processed with colloidal silica at varying ratios (95:5, 96:4, 97:3, 98:2 and 99:1). Preliminary screening was conducted on the five combinations by determining the crushing...