Posts tagged with "coamorphous system"


Graphic which shows the interaction strength of drug and excipient in relation to time
18. January 2018

Drug-excipient interactions - ketoconazole-organic acid coamorphous systems

The use of excipients other than polymers for enhancing the physical stability of amorphous active pharmaceutical ingredients (APIs) has largely been unexplored. We investigated several organic acids (oxalic, tartaric, citric and succinic acid) for the purpose of stabilizing a weakly basic API, ketoconazole (KTZ), in the amorphous state.

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