14. December 2016

Topical hydrogel preparations are applied on skin to obtain local or systemic action. NSAID’s are non-steroidal drugs having excellent anti-inflammatory and analgesic activity but it produces GIT ulceration when used orally. To overcome that problem with oral formulations, many NSAID’s are preferred to be administered by topical route. The present investigation is aimed to formulate the hydrogel of Diclofenac potassium with different ratio of Carbopol of different grades along with guar gum...

24. October 2016

Purpose Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work aims to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Methods Fifteen DSV matrix formulations were prepared using different polymers, polymer/drug ratios and matrix excipients and characterized using Differential Scanning Calorimetry (DSC), infra-red (IR)...

15. June 2016

Abstract In this study, terahertz time-domain spectroscopic (THz-TDS) technique has been used to ascertain the change in the optical properties, as a function of changing porosity and mass fraction of active pharmaceutical ingredient (API), of training sets of pharmaceutical tablets. Four training sets of pharmaceutical tablets were compressed with microcrystalline cellulose (MCC) excipient and indomethacin API by varying either the porosity, height, and API mass fraction or all three tablet...

05. April 2015

Purpose Intravenous injections of propofol emulsions are accompanied by pain likely due to the interaction of the dissolved drug with endothelial cells of the vasculature. It is commonly hypothesized that reducing the aqueous phase concentration of propofol could reduce pain. http://www.sciencedirect.com/science/article/pii/S0378517315002732