24. August 2017
The flowing properties of 10 lactose powders commonly used in pharmaceutical industries have been analyzed with three recently improved measurement methods. The first method is based on the heap shape measurement.
23. August 2017
Moisture is known to affect the flowing properties of powders. However, the quantification and the understanding of the observed effects are far to be obvious.
20. April 2017
Abstract The purpose of this study is to demonstrate that the flow function (FFc) of pharmaceutical powders, as measured by rotational shear cell, is predominantly governed by cohesion, but not friction coefficients. Driven by an earlier report showing an inverse correlation between FFc and the cohesion divided by the corresponding pre-consolidation stress [Wang et al. 2016. Powder Tech. 294:105-112], we performed analysis on a large dataset containing 1130 measurements from a ring shear...
15. August 2016
Abstract The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carr index (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very common in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic silica on a poorly flowable active pharmaceutical ingredient (ibuprofen) by different flow characterization techniques. Different percentages (0.5, 1.0, and 2.0 wt%) of both types of mixed...
04. July 2016
Abstract This study investigates the relationship between particle interactions dominated by the cohesive van der Waals force and powder flowability for materials commonly used by the pharmaceutical industry in oral solid dosage formulation. This study first sought to correlate the granular Bond number, defined as the ratio of the inter-particle cohesion force to particle weight, to the flow function coefficient, a metric commonly used to assess powder flowability. However, the granular Bond...