08. November 2017
Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG).
02. March 2016
Aim: To evaluate possible interaction between apple cider vinegar (ACV) which is the most frequent used active ingredient of diet pills with 20 different excipients. Materials and Methods: The pure drug ACV and drug-excipient powder mixtures which were stored under the condition of 40°C and 75% relative humidity for a period of 21-day and interaction were seen by using modern instrumental technique high-performance liquid chromatography, Fourier transmission infrared and differential scanning...
03. December 2015
Background Many excipients have been reported to induce drug hypersensitivity (e.g. colouring additives, preservatives). Colloidal silica has never been reported to induce drug hypersensitivity reactions. Case report We report herein a 40-year-old patient who developed a skin eruption 2 days after Voltarene® (diclofenac) intake, confirmed by a positive patch test. Investigation of cross reactivity, assessed by patch testing to other non steroidal anti-inflammatory drugs, have showed a positive...
20. April 2015
ABSTRACT The aim of this study was to evaluate the direct compression behaviour of co-processed cassava starch and colloidal silica in the formulation of metronidazole tablets. Cassava starch was extracted from freshly harvested roots of Manihot glaziovii obtained from IITA farms, Shika, Zaria. Subsequently, it was co-processed with colloidal silica at varying ratios (95:5, 96:4, 97:3, 98:2 and 99:1). Preliminary screening was conducted on the five combinations by determining the crushing...