26. December 2017
Micro sponge is a novel approach for targeting the drug to the colon for the management of colon ailments such as inflammatory bowel disease. Prednisolone loaded microsponges (PLMs) were prepared and coated with Eudragit S 100 (ES) and evaluated for colon specific drug delivery.
08. November 2017
Colon delivery systems for oral administration have grown in popularity since the 1990s, primarily because of the increasing incidence of inflammatory bowel disease (IBD) that has broadly been demonstrated to benefit from topical pharma- cological treatment.
07. October 2017
SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant β-lactamase enzyme designed to degrade β-lactam antibiotics administered intravenously, and thus prevent colon dysbiosis. Here we describe the development of the SYN-004 enteric coated pellet formulation, which has been tested in multiple clinical trials. Since the SYN-004 drug substance is a buffered liquid, several binder excipients in different ratios were tested to...
20. September 2017
Abstract The objective of this study was to evaluate the combination of pH-dependent and time-dependent polymers on drug release in order to optimize coating for colonic delivery. Response surface methodology (RSM) based on central composite design (CCD) was employed for formulation optimization. Theophylline was used as model drug and Eudragit® FS 30D and hydroxypropyl methylcellulose (HPMC) were used as pH-dependent and time-dependent polymer, respectively. Dissolution test was carried out...
03. April 2017
ABSTRACT The aim of the present work was to develop and evaluate sustained release colon targeted micropellets of lornoxicam in order to achieve release of the drug at colon which could result in enhanced local absorption and thereby improved bio-availability. The present worker prepared micropellets of lornoxicam in nine batches using pure drug, DCP, PVPK-30 and different ratios of HPMCK-4M taking into account the direct pelletization technique. Resulted micropellets were illed in capsules and...
16. March 2017
Abstract A doubly enteric-coated multiple-unit tablet (DET) of bisacodyl (BD) was formulated to selectively deliver the stimulant laxative to the large intestine. Solubilized BD in surfactants was adsorbed into the porous carrier and primarily coated with different combinations of pH-sensitive polymers (Eudragit S and Eudragit L) and time-dependent release polymer (Eudragit RS). BD-loaded granules were compressed into tablets and coated again with pH-sensitive polymers (Eudragit S:Eudragit L =...
09. February 2017
Abstract: Background: Colorectal carcinoma is the fourth most common internal malignancy; it is second only to carcinoma of the lung as a cause of carcinoma death. 6-Mercaptopurine (6-MP) is a drug of choice in the treatment of Crohn's disease, ulcerative colitis and colorectal cancer. The drug shows irritation on gastric exposure. It has poor bioavailability with half life less than 2 h. Targeted delivery of 6-MP will provide an effective and safe therapy for colon diseases. Objective:...
06. November 2016
Abstract Herbal medicines are recognized as an effective treatment of common diseases, mainly associated with oxidative stress. Therefore developing drug delivery systems of these biological active ingredients are gaining interest. Parsley (Petroselinum crispum L.) is a well-known culinary herb and its leaf contains high amount of apigenin, therefore it is suitable as a natural source of this flavonoid. Apigenin possess many health effects such as antioxidant, anti-inflammatory and anticancer...
18. September 2016
Inflammatory bowel disease (IBD) is an idiopathic, relapsing disease involving chronic inflammation of the digestive tract, either in part or entire. IBD primarily includes Crohn’s disease (CD) and ulcerative colitis (UC) with a high prevalence rate in the industrialized world, with North America noting the highest frequency of people suffering with CD [1]. Incidence of IBD is from 31 to 71 per100,000 people for CD and 18-31 per 100,000 for UC and is increasing at an alarming rate. Although,...
14. August 2016
Abstract A multiple-unit formulation for time-dependent colonic release of insulin was obtained by coating insulin and sodium glycocholate immediate-release minitablets with: i) Methocel® E50, a low-viscosity hydroxypropyl methylcellulose (inner coating); ii) 5:1 w/w Eudragit® NE/Explotab® V17, a mixture of a neutral polymethacrylate with a pore-forming superdisintegrant (intermediate coating); iii) Aqoat® AS, enteric-soluble hydroxypropyl methylcellulose acetate succinate (outer coating)....