20. February 2017

Abstract The aim of present work was to investigate the role of liquisolid technique in improving dissolution of high dose Progesterone. Progesterone-PEG 400 dispersions were prepared and evaluated for technological properties, and further formulated into liquisolid tablets using Neusilin US2 and Syloid 244 FP as a carrier and coat respectively. Due to polymorphic behavior of Progesterone, liquisolid tablets were investigated by XRPD, DSC and SEM, whereas, improvement in dissolution was studied...

09. May 2016

The present research is focused on developing a novel, scaled-down approach based on the liquid droplet-powder bed interactions for the estimation of an optimal liquid to solid ratio (L/S) required in the twin screw wet granulation. A single droplet ‘powder-bed-nucleation’ process using compacted powder beds of α-lactose monohydrate (soluble) and microcrystalline cellulose (insoluble, swells upon water addition) with varying proportions of hydroxypropyl cellulose, was used to produce wet...