31. January 2018
Excipients serve a critical role in the production of final dosage forms for drug products and biologics. They facilitate the manufacturing process (e.g., anticaking agents) and protect, support, and enhance stability. They may also improve bioavailability. In addition, excipients help maintain the safety, or function, of the product during storage and use.
No longer characterized as inert accompaniments to an active pharmaceutical ingredient (API), excipients are the target of an intensified p
19. October 2017
Silica is a common excipient, which makes porous silica particles excellent candidates for use in pharmaceutical and nutraceutical products as unique identifiers.
10. August 2017
Around half of all medications for chronic diseases are not taken as prescribed, costing the U.S. health care system more than $100 billion in avoidable hospital stays each year.
07. August 2017
Jason Teckoe, technical director, Colorcon EMEA, discusses the important considerations when coating oral solid dosage forms.
Jason Teckoe
Jason Teckoe, technical director, Colorcon EMEA
Tablets remain the most common solid oral dosage form for many reasons, including ease of manufacture, convenience for the patient, accurate dose administration and good stability. Good tablet design can be used to provide product differentiation, avoid medication mix-ups and deter counterfeiting.
11. July 2017
Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for prescription and over-the-counter medications. In contrast to classical tablets, ODTs are specifically designed to disintegrate directly in the patient's mouth. The disintegrated tablet can then be swallowed easily without any resistance. BASF offers a comprehensive set of excipients that help you to easily formulate your active ingredient
08. March 2017
ABSTRACT: Topiramate (TPM) is effective for multiple seizure types and epilepsy syndromes in children and adults. Topiramate has adverse effects (including cognitive, depression, renal stones), but many of these are low incidence when started at a low dose and slowly titrated to 100 to 200 mg/day. Also, TPM has proven benefit for migraine, obesity, eating disorders, and alcohol use disorders, which can be comorbid in patients with epilepsy and may also be effective in subpopulations within...
24. May 2016
The present investigation is an attempt to design and evaluate rapidly dissolving oral strips of metoprolol succinate, an anti-hypertensive agent. Rapidly dissolving oral strips were prepared by solvent casting technique using hydroxyl propylmethylcellulose-5 cps and polyvinyl alcohol as the lm forming polymers. The prepared strips were evaluated for the characteristics such as thickness, folding endurance, percent elongation, tensile strength, surface pH, percent drug content, in-vitro...
01. May 2016
Objective: Tablet is still most popular conventional dosage forms existing today, but the drawback of solid dosage forms is the difficulty in swallowing (dysphagia) or chewing in some patients particularly pediatric and geriatric patients. For this reason, orodispersible tablets (ODT) that can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. The main objective of this review is to explore various methodologies for masking the taste of obnoxious...
