07. May 2018
The aim of this research was to design and evaluate a hydrophilic matrix system for sustained release of glipizide, a weakly acidic poor soluble drug. A combination of inclusion complexation and microenvironmental pH modification techniques was utilized to improve the dissolution and pH-independent release of glipizide. Hydroxypropyl-β-cyclodextrin (HP-β-CD) was used as the complexation agent while sodium citrate and magnesium oxide (MgO) were used as model pH modifiers. The hydrophilic...
22. January 2018
In this study, we developed pH-triggered surface charge-reversal lipid nanoparticles (LNPs), loaded with budesonide, which could precisely deliver the drug to inflamed colon segments for the treatment of ulcerative colitis.
01. December 2014
Vincent Jannina, , , Yvonne Rosiauxa, Jean Doucetba Gattefossé SAS, 36 chemin de Genas 69804 Saint-Priest cedex, Franceb Novitom SAS, 1 Firmin Gautier 38000 Grenoble, France http://www.sciencedirect.com/science/article/pii/S0168365914007500