28. November 2017
Particle design via spherical agglomeration is a size enlargement technique used in various bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in which an immiscible bridging liquid is added to agglomerate crystals prior to deliquoring. Spherical agglomeration has the potential to dramatically simplify downstream processing, and improves the handling of difficult, needle-shaped crystals. This review consolidates the understanding of the controlling process...
22. May 2017
This paper introduces a novel continuous heterogeneous crystallization process in which the active pharmaceutical ingredient is crystallized directly on the surface of an excipient within the crystallizer. The product is subsequently dried and formed into tablets without the need for complex downstream processing steps, in which the aim is to eliminate many steps of the particle processing in drug product manufacturing.
24. June 2015
Formulating drugs in the amorphous form is an attractive and promising strategy to overcome the poorly water soluble challenge commonly encountered in the newly discovered drug. The active research in the investigation of the properties and performance of drugs in the amorphous form has revealed the major challenges in developing amorphous formulations into marketable products. The three main challenges are development of analytical techniques to characterise the amorphous formulations,...