28. December 2015
In this work, we have quantified effects of moisture content, over the relative humidity (RH) range of 5–92% corresponding to 1.6–10.9% of water content, on flow properties of a grade of microcrystalline cellulose (Avicel PH102) using a ring shear cell. Several key powder flow parameters, including cohesion (τc), unconfined yield strength (fc), powder bulk density (ρb), flowability (ffc), and effective angle of internal friction (ϕe), were assessed. More
28. December 2015
The aim of this study was to investigate the effect of combination lipophilic (Acryl-EZE®) and hydrophilic (HPMC) polymers on the release of Sodium Diclofenac (DS) from a tablet. The microgranules were prepared using a fluidized bed followed by direct compression. Swelling and erosion studies of polymer matrix tablets were carried out in various media. More
27. December 2015
Amorphous calcium carbonate (ACC) is known to interact with proteins, for example in biogenic ACC, to form stable amorphous phases. The control of amorphous:crystalline and inorganic:organic ratios in inhalable calcium carbonate microparticles may enable particle properties to be adapted to suit the requirements of dry powders for pulmonary delivery by oral inhalation. More
26. December 2015
Dalbergia sissoo gum was purified by ethanol precipitation. The purified gum was modified and hydrolyzed. Gum was modified by performing polyacrylamide grafting and carboxymethylation methods. The hydrolysis was carried out by using mannanase, barium hydroxide and trifluoroacetic acid. More
26. December 2015
Biopolymers are naturally occurring polymeric biomolecules. They are easily accessible, relatively cheap, can be synthetically altered and biodegradable. Locust bean gum and Xanthan gum is widely used ingredient in drug formulations due to their non interacting behavior with the drug and less toxicity. Microparticle formulations of celecoxib, a COX-2 inhibitor were formulated using Locust bean gum and Xanthan gum. More