08. February 2017

FDA and USP Workshop on Standards for Pharmaceutical Products February 27–28, 2017 USP Meetings Center, Rockville, MD USA More Information and Registration

31. December 2016

Abstract This study aimed to develop a mucoadhesive polymeric excipient comprising curcumin for buccal delivery. Curcumin encompasses broad range of benefits such as antioxidant, anti-inflammatory, and chemotherapeutic activity. Hyaluronic acid (HA) as polymeric excipient was modified by immobilization of thiol bearing ligands. L-Cysteine (SH) ethyl ester was covalently attached via amide bond formation between cysteine and the carboxylic moiety of hyaluronic acid. Succeeded synthesis was...

31. December 2016

The powder blending process is often identified as a challenging operation in solid dosage form manufacturing. On one hand, inadequate blending leads to poor active ingredient/excipient mixing. On the other hand, excessive blending could potentially deleteriously affect the drug content uniformity the final product. Mixing behavior is complex and can be affected by various chemical and physical properties of the solid materials like density, particle size, particle shape, and surface energy....

31. December 2016

Bioavailability of a poorly water-soluble drug can be improved by preparing its aqueous nanosuspension in the presence of various stabilizers via wet milling and subsequently drying the suspension into nanocomposite microparticles or shortly nanocomposites. Unfortunately, drug nanoparticles aggregate during milling and drying, causing incomplete recovery and relatively slow dissolution from the nanocomposites. While various stabilizers/dispersants can be used to mitigate the extent of...

29. December 2016

Abstract Fast dissolving tablets (FDTs) have received more interest in the pharmaceutical industry for those categories of drug which show slow dissolution and less oral bioavailability. Nowadays various technologies have been developed for FDTs with improved patient compliance and convenience. FDTs tablets provide an advantage particularly for the pediatric and geriatric patients who have difficulty in swallowing and also for that who are travelling for a long and suffers from lack of water...

29. December 2016

Abstract Among all biomass sources, cellulose is the most diverse material sourced from plants and is abundant in nature. It possesses some promising properties such as biodegradability, biocompatibility and hydrophilicity. In several industrial biomasses, the waste products especially for food manufacture have high content of cellulose and their disposals are serious in reuse problem. Therefore, people have given attention with regard to their regeneration to the useful materials. In this...

29. December 2016

Abstract A process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new way to dosage forms showing enhanced drug release. The process consists of a fluidized bed operated at elevated pressure in which API particles are precipitated from a Supercritical Anti-Solvent process (SAS). MCC particles were used as an excipient in the fluidized bed and collect the SAS-generated API particles. Naringin was selected as the...

28. December 2016

Abstract Current endeavor was aimed towards monitoring percent weight build-up during functional coating process on drug-layered pellets. Near-infrared (NIR) spectroscopy is an emerging process analytical technology (PAT) tool which was employed here within quality by design (QbD) framework. Samples were withdrawn after spraying every 15-Kg cellulosic coating material during Wurster coating process of drug-loaded pellets. NIR spectra of these samples were acquired using cup spinner assembly of...

28. December 2016

Aim: The main objective of the present investigation was to formulate and characterize an oral pulsatile drug delivery system of flurbiprofen, for time dependent release, based on chronomodulated approach for the management of rheumatoid arthritis. Settings and Design: The drug delivery system was designed to deliver the drug with a lag time to release the drug when it could be most needful to patients of rheumatoid arthritis. Materials and Methods: Rapid release core tablets of flurbiprofen...

28. December 2016

Introduction: Diabetes mellitus (DM) is a worldwide disease with high mortality rate. Metformin hydrochloride has been used as the first-line drug for the treatment of DM Type 2. However, the high water solubility and short half-life lessen the potential effectiveness of using conventional metformin tablet. Floating tablet is an attractive pharmaceutical formula which can make the drugs staying with an adequate time in the absorption part of the gastrointestinal tract (i.e., the stomach), and...