13. March 2018
For their nutritional and medicinal advantages, several bioactive compounds and ingredients are being used in the production of medical foods, functional foods and dietary supplements. As health consciousness among consumers increases, the demand for dietary supplements will witness an upsurge. In order to attain a stabilized manufacturing of these products, a range of nutraceutical excipients will be utilized.
31. January 2018
Multiple brands of the same active ingredient may be available for the same strength, administration route and dose form. Generic brands needs to demonstrate bioequivalence to the originator brand, but the appearance of the generic and originator brands are not required to match.
17. October 2017
To gain a better understanding of disintegration actions, 11 different disintegrants were tested. Model tablets were prepared with various preparation conditions, and their disintegration time and tensile strength were measured.
16. February 2017
Abstract Spironolactone is a drug derived from sterols that exhibits an incomplete oral absorption due to its low water solubility and slow dissolution rate. In this study, formulations of spironolactone with four disintegrants named as croscarmellose sodium, crospovidone, sodium starch glycolate and microcrystalline cellulose II (MCCII) were conducted. The effect of those disintegrants on the tensile strength, disintegration time and dissolution rate of spironolactone-based compacts was...
23. May 2015
Disintegrant is a typical excipient that improves the solubility, dissolution and bioavailability of drug. In this study, the application of nanocrystalline cellulose (NCC) as a potential disintegrant in the preparation of tablet was investigated... http://www.sciencedirect.com/science/article/pii/S0144861715004051