29. January 2018
In this study, we evaluated contact lenses as drug delivery media and the effect of tear physiological pH on drug release behavior. Anionic or cationic hydroxyethyl methacrylate (HEMA) lenses were polymerized with either vinylpyrrolidone (VP) or N-isopropylacrylamide (NIPAAm). The pH of artificial tears was prepared as between 5.8 and 8.35. One of common treatments, hydroxypropyl methylcellulose (HPMC), to dry eye disease was used as a test drug.
09. October 2017
A preclinical rabbit model of DED was created and animals were treated with the conceptually novel compound HASD to measure the clinical potential of this novel compound. While it performed well – at least as well as the best artificial tear solution Systane Ultra – this comparison is perhaps unfair to HASD