02. August 2016
ABSTRACT Introduction: Many abuse-deterrent formulations (ADFs) rely on being crush resistant and extraction resistant in order to provide deterrence to abuse by insufflation and injection, respectively. High molecular weight polymers such as poly(ethylene oxide) are commonly used to provide this deterrence. However, these polymers suffer from slow dissolution kinetics, and are susceptible to variety of abuse conditions. Objective: This study was aimed to determine if selected superabsorbent...
13. June 2016
In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER) combined with alcohol dose dumping (ADD) resistance. The pellets were prepared via wet/extrusion spheronization and ER characteristics were obtained after fluid bed drying at 30 °C. Pore blockers (i.e., xanthan, guar gum and TiO2) were integrated to control the uptake of ethanolic media, the CaSt swelling and consequently, the COP release....
05. March 2016
Almost all drugs are rapidly and completely absorbed form gastrointestinal tract. But some drug having problems like first pass metabolism, low bioavailability, chances of dose dumping, unstability at colonic pH, produced gastric irritation when administered in single unit dosage form or disturbed normal colonic bacterial flora. It creates the need to design safer and effective drug delivery systems. The floating microspheres are one of the most promising multiparticulates drug delivery system...
28. October 2015
This article looks at the current status of alcohol-induced dose dumping of modified-release formulations and the need for regulatory harmonization in handling this challenge. More