07. October 2017
Burst drug release is often considered a negative phenomenon resulting in unexpected toxicity or tissue irritation. Optimal release of a highly soluble active pharmaceutical ingredient (API) from hypromellose (HPMC) matrices is technologically impossible; therefore, a combination of polymers is required for burst effect reduction. Promising variant could be seen in combination of HPMC and insoluble Eudragits® as water dispersions. These can be applied only on API/insoluble filler mixture as...
10. August 2017
Oral drug products such as tablets, capsules and solutions contain the active ingredient (medication) and various other ingredients that are considered to be therapeutically inactive. These inactive ingredients, called excipients, are included in oral products for various reasons, such as to enhance the stability of the active ingredient or change the color or taste.
07. August 2016
Abstract To develop a matrix-type, controlled-release tablet formulation of pelubiprofen (PLB), a recently developed non-steroidal anti-inflammatory drug, polymeric excipients including hypromellose, hydroxypropylcellulose, Eudragit® RS PO, and Kollidon® SR were screened. A formulation containing 12.4%w/w Kollidon® SR (K2 tablet) was found to be the most promising and stable for 6 months in an accelerated stability test. PLB release from K2 tablet was limited at pH 1.2, but gradually...
02. May 2016
Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile; prime requisites considered during the selection of any excipient in formulation development. Areas covered: The individual properties and applications of PEG have been discussed at length in the existing literature. However, guidance on proper selection of PEG grade to cater to one’s purpose is...
22. August 2015
Purpose Currently, the FDA allows biowaivers for Class I (high solubility and high permeability) and Class III (high solubility and low permeability) compounds of the Biopharmaceutics Classification System (BCS). Scientific evidence should be provided to support biowaivers for BCS Class I and Class III (high solubility and low permeability) compounds. Methods Data on the effects of excipients on drug permeability are needed to demonstrate that commonly used excipients do not affect the...
25. February 2015
Newborn babies can require significant amounts of medication containing excipients intended to improve the drug formulation. Most medicines given to neonates have been developed for adults or older children and contain excipients thought to be safe in these age groups. Many excipients have been used widely in neonates without obvious adverse effects. Some excipients may be toxic in high amounts in which case they need careful risk assessment.......
15. January 2015
as Active Pharmaceutical Ingredient Inside Tablets AAPS PharmSciTech January 2015 http://link.springer.com/article/10.1208/s12249-014-0276-7