03. October 2017

Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to facilitate the optimal transmission of light. At the air–water interface, the tear film lipid layer (TFLL), a mixture of lipids and proteins, plays a key role in tear surface tension and is important for the physiological hydration of the ocular surface and for ocular homeostasis. Alterations in tear fluid rheology, differences in lipid composition, or downregulation of...

20. March 2017

Abstract Local ocular delivery of cyclosporine A (CsA) is the preferred method for CsA delivery as a treatment for ocular inflammatory diseases such as uveitis, corneal healing, vernal keratoconjunctivitis and dry eye disease. However, due to the large molecular weight and hydrophobic nature of CsA and the natural protective mechanisms of the eye, achieving therapeutic levels of CsA in ocular tissues can be difficult. This review gives a comprehensive overview of the current products available...

14. July 2016

As a novel drug delivery approach, piroxicam an anti rheumatoid drug is loaded in microspheres prepared by chitosan as a polymer and coated with eudragit S-100 to prepare colon speci c microspheres which increases the bioavailability of the drug to the targeted area and in a controlled manner and reduces GI related side effects. In the present study chitosan microspheres were prepared using emulsion crosslinking technique, glutaraldehyde as a crosslinker and microencapsulation using phase...

16. May 2016

To study the effect of hydrophobic modification of the emulsifier on the relationship between emulsion stability and polymer emulsifier concentration, silicone oil emulsions were prepared using by hydroxypropyl methylcellulose (original HPMC) and HPMC stearoxy ether (hydrophobic HPMC) at concentrations around their overlap concentrations. Both HPMC types completely emulsified the silicone oil. However, the volume fraction of silicone oil in the emulsion prepared using hydrophobic HPMC was less...

12. March 2016

Abstract: Cellulose ethers are usually used as secondary emulsifiers. Different types of commercial hydroxypropylmethylcellulose (HPMC) have been used here as the main emulsifier of oil-in-water emulsions to probe their impact on the lipid digestibility under simulated intestinal conditions. The droplet size distribution and ζ-potential of the emulsions subjected to in-vitro lipolysis have been compared with that of control samples (non-digested). The lipolysis has been quantified over time by...

23. December 2015

Purpose of this study was to investigate the ability of octenyl succinic anhydride (OSA) starch as emulsifier and solid carrier in dry emulsion (DE) and dry suspension (DS) formulations. Fenofibrate (FF) was loaded at lower and higher than its saturation concentration in oil phase to prepare the DE and DS by spray drying method. More

15. December 2015

Polymer nanoparticles (NPs) represent a promising way to deliver poorly water-soluble anticancer drugs without the use of unwanted excipients, whose presence can be the cause of severe side effects. More

27. October 2015

Highlights • Βacterial Cellulose (BC) can adsorbed onto the WPI-coated emulsions and form a second layer. • Stable emulsions were obtained due to either steric stabilization or network formation of BC fibrils. • BC could act as a cheaper alternative thickener for o/w emulsions. More

13. September 2015

The purpose of the present study was to develop the Solutol HS15-based doxorubicin submicron emulsion with good stability and overcoming multi-drug resistance. In this study, we prepared doxorubicin submicron emulsion, and examined the stability after autoclaving, the in vitro cytotoxic activity, the intracellular accumulation and apoptpsis of doxorubicin submicron emulsion in MCF-7/ADR cells. The physicochemical properties of doxorubicin submicron emulsion were not significantly affected after...

08. June 2015