20. November 2016

Abstract In this study a multiparticulate matrix system was produced, containing two different APIs: enalapril-maleate and hydrochlorothiazide. The critical control points of the process were investigated by means of factorial design. Besides the generally used microcrystalline cellulose, ethylcellulose was used as matrix former to achieve modified drug release ensured by diffusion. The matrix pellets were made by extrusion-spheronization using a twin-screw extruder. Some pellet properties...