20. April 2017

Abstract Objective: The aim of this work was to investigate the potential of controlled precipitation of flurbiprofen on solid surface, in presence or absence of hydrophilic polymers, as a tool for enhnaced dissolution rate of the drug. The work was extended to develop rapidly disintegrated tablets. Significance: This strategy provide simple technique for dissolution enhancement of slowly dissolving drugs with high scaling up potential. Method: Aerosil was dispersed in ethanolic solution of...

02. June 2015

Close to 40% of the currently marketed drugs fall into the two low solubility Biopharmaceutical Classification System (BCS) categories; furthermore, if looking at the pipeline of drug entities under discovery or in development, this number increases to 80%. This trend towards low solubility will see the market for solubility enhancement excipients grow at a compound annual growth rate of nearly 13% in the period from 2014 to 2024.1 And the overall pharmaceutical excipients market is expected to...