16. February 2017

ABSTRACT Amiodarone is antihypertensive drug with variable bioavailability following oral administration due to poor solubility and pre-systemic metabolism. Accordingly, the study strategy was to enhance the dissolution rate of the drug by solid dispersion (SD) and surface solid dispersion (SSD) techniques, with optimum formulations being developed as fast disintegrating tablets with rapid release. Binary and ternary SD were prepared using Pluronic F68, Pluronic F127 and PVP k30 as the...

13. November 2015

Various techniques are being followed to achieve increased solubility of the drug compounds depending upon active pharmaceutical ingredients (API) characteristics, formulator’s capabilities, and relative cost effectiveness of the strategies. Among advanced solubility enhancement technologies, the most important ones are solid dispersions and lipid solubilization. In fact, lipid excipients are the largest category of solubility enhancement excipients because of their large levels of use in...