29. March 2018
Docetaxel (DTX) is a chemotherapy drug that can be used for different type of cancers. Due to polysorbate 80, the excipient in the formulation, acute hypertensivity reaction is observed after intravenous administration. The development of oral formulation for DTX has always been problematic as the bioavailability of the drug is shown to be low due to P-glycoprotein efflux transporters and the intestinal metabolism by CYP3A4 enzymes. The objective of this study is to develop novel DTX in situ...
08. March 2017
Abstract Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would deliver this hydrophilic anti-HIV drug to the reticuloendothelial system for better therapeutic efficacy. The objectives of the current study were to prepare and pharmaceutically characterize...
03. March 2017
Abstract A 23 Factorial design of cissus-gelatin B polymer blends was developed to formulate amodiaquine HCl-artesunate (AQ-AS) microparticles by varying the polymer blend concentration (2 %w/v, 5 %w/v), crosslinking time (0.5 h, 1 h) and glutaraldehye volume (0.5 ml, 1 ml). The formulations were evaluated using drug entrapment efficiency (EE), particle size, polydispersity index, thermal behaviour with differential scanning calorimetry, crystallinity with powder X-ray diffraction, morphology...
06. May 2016
The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems,...
08. April 2016
Aim: The main objective of the present research work was to develop floating microspheres of cefditoren pivoxel (CP) to provide the delivery of the drug at a sustained rate. Materials and Methods: Floating microspheres of CP were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC) K4M and ethyl cellulose as the rate controlling polymers. The optimization of formulation was carried out by 32 factorial design using two factors; a total amount of polymer (X1) and...