04. October 2018
The aim of this work was to develop an ascending controlled-release pellet (ACRP) of paliperidone to improve poor solubility and provide a stable blood drug concentration. The inner core was produced by mixing different ratios of sodium chloride as an osmotic substance and microcrystalline cellulose (MCC) to offer a pressure drive when in contact with medium. After, the drug layer was processed by a liquid-layering method, with paliperidone ground to a nano-size in order to improve the...
04. April 2017
Abstract The objective of this study was to develop Esomeprazole solid dosage form as minitablets. The effect of coating thickness and percentage of fast disintegrants on the in vitro and in vivo performance of minitablets were studied. Two formulae (A1&B1) of the same core composition with different coat thickness were prepared initially. The in vivo study of A1 and B1 versus the originator revealed that their rate of dissolution was not enough to achieve bioequivalence with respect to...
28. July 2016
Abstract Multiparticulate formulations are composed of multiple solid dosage units which can be administered directly to the mouth or sprinkled on food. Oral grittiness (i.e. rough mouthfeel) may arise from the presence of particles in the mouth, limiting palatability. In this work, multiparticulate formulations were prepared by dispersion of spherical granules into orange flavoured vehicles thickened with hypromellose (HPMC) at different viscosities in order to assess oral perception of...
24. May 2016
Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an...