22. February 2018
Synopsis Fluidized bed granulation (FBG) is a commonly known and highly complex process in the pharmaceutical industry. In-line spatial filter velocimetry (SFV) analysis for particle size measurement provides a promising approach to enhance process control and efficiency. In the present study investigations of the installation height and the influence of differing process parameters on in-line SFV analysis were evaluated. Materials and Methods A blend of Cellets (Harke Pharma GmbH, Germany) was...
02. April 2017
Abstract Artemisinin, a natural anti-malarial agent, also possesses anti-proliferative and anti-angiogenic activity in cancer cells with very low toxicity to normal healthy cells. Drug loaded magnetic nanoparticlesby using external magnetic field could selectively accumulate the drug at the target site and thereby reduce the doses required to achieve therapeutic concentration which may otherwise produce serious side effects on healthy cells. In the present study the artemisinin magnetic...
17. January 2017
Objectives The aim of this review was to map the currently available evidence on acceptability of oral paediatric medicines to aid in the selection of suitable platform formulations for the development of new acceptable paediatric products. Methods This process used a defined search strategy of indexed publications and included methods to assess the quality of the evidence retrieved. Key findings Taste/palatability was the most extensively studied area of paediatric medicine acceptability yet...
13. March 2016
Purpose: The majority of contact lens wearers experience a significant level of ocular discomfort associated with lens wear, often within hours of wear, related to dry lenses, inflammation, protein adhesion to the lens surface, etc. Application of controlled drug release techniques has focused on the incorporation and/or release of a single comfort molecule from a lens including high molecular weight comfort agents or pharmaceutical agents. Previous studies have sought to mitigate the...
18. February 2016
Purpose Aiming to improve the dissolution rate of ezetimibe (EZE) and lovastatin (LOV) in a fixed dose combination (FDC), co-amorphous systems and ternary solid dispersions were prepared by quench cooling and spray drying, respectively. Methods Formulations were characterized through X-ray diffraction, modulated differential scanning calorimetry, infrared spectroscopy, scanning electron microscopy and laser diffraction, and evaluated by ‘in vitro’ dissolution. Stability studies were...
19. December 2015
The concept of Quality by Design is of increasing importance in the pharmaceutical industry, especially in the development of biotechnologically produced active pharmaceutical ingredients (APIs). These proteins/peptide-like materials are usually more sensitive than small molecules to the environmental and process parameters. More
02. November 2015
Particle size and shape are well known to play important roles in particle formation and processing as they influence the intermediate and final products directly. Their effects are especially important in the manufacturing of mini tablets 2-3 mm in diameter. More