20. June 2018
The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by...
13. April 2018
In recent years, the application of polymeric materials for a targeted drug-delivery system has been greatly advanced. Since polymeric materials played a crucial role in the targeted drug-delivery technology, the selection of such materials is very important in formulation and development. Polymeric materials used as components of the drug-delivery system should not be toxic and must have the desired essential properties required for such developments. Nowadays, research is much focused on the...
08. April 2017
During the early stages of drug development, a compound is often solubilised to create a liquid formulation that can be used to evaluate the pharmacokinetics, pharmacology and toxicology of a substance. Although a critical aspect in formulation development, solubility remains one of the most difficult obstacles to overcome due to many compounds possessing low aqueous solubility. Consequently, selecting the right excipient is vital to improve the solubilisation capacity of a drug. There are...