22. November 2017
Background and Objective: Single-unit solid oral dosage forms such as tablets and capsules are considered the most common and acceptable form of immediate release systemic drug delivery systems. On the other hand, multiple-unit pellet systems (MUPS) have in recent years become an important dosage form that offers various advantages over conventional single-unit solid oral dosage forms.
13. December 2016
Abstract Partially hydrolysed polyvinyl alcohol (PVA) was evaluated as a pelletisation aid for the production of pellets with a high acetaminophen and metformin hydrochloride concentration (>70%, w/w). Mixtures with varying drug concentration and PVA/microcrystalline cellulose (MCC) ratios were processed via extrusion-spheronisation, either after addition of PVA as a dry powder or as an aqueous solution. Finally, high drug- loaded metformin pellets were coated with a methacrylic acid...
22. July 2015
We present a novel but simple enteric coated sphere formulation containing probiotic bacteria (Lactobacillus casei). Oral delivery of live bacterial cells (LBC) requires live cells to survive firstly manufacturing processes and secondly GI microbicidal defenses including gastric acid. More